N-苄氧羰基-3-氟-4-吗啉基苯胺的合成

Synthesis of N-Carbobenzoxy-3-fluoro-4-morphlinylaniline

目的研究新的适合大工业生产的合成N-苄氧羰基-3-氟-4-吗啉基苯胺的方法。方法以3,4-二氟硝基苯和吗啉为原料,经取代,还原,取代三步得到N-苄氧羰基-3-氟-4-吗啉基苯胺。结果通过新的方法成功合成出了N-苄氧羰基-3-氟-4-吗啉基苯胺,总收率达到73%,后处理方便。结论新方法是一种合成N-苄氧羰基-3-氟4-吗啉基苯胺的好方法。

Objective To develop new method to synthesize N-Carbobenzoxy-3-fluoro-4-morphlinylaniline complying with the requirements of the industrialized mass production. Methods N-Carbobenzoxy-3-fluoro- 4-morphlinylaniline was synthesized from 3,4-difluore-nitrobenzene and morpholine via substitution, reduction, substitution. Results N-Carbobenzoxy-3-fluore-4-morphlinylaniline was synthesized successfldly with total yield 73% and convenient disposition by the new method. Conclusion It is a goodway to synthesize N-Carbo- benzosy-3-fluore-4-morphlinylaniline using the new method.