多潘立酮与西沙必利治疗早产儿胃潴留的疗效比较

Comparison of Domperidone and Cisapride in Treating Gastric Retention of Premature Infants

目的:对多潘立酮与西沙必利治疗早产儿胃潴留的临床疗效进行比较。方法:选择1996年以来我院收治的符合胃潴留诊断标准的51例胃管喂养早产儿,随机分为多潘立酮组与西沙必利组,多潘立酮按0.3 mg/(kg.次)、西沙必利按0.2 mg/(kg.次)于喂奶前30 min胃管注入,3次/d,疗程5～7 d。结果:多潘立酮组23例中显效12例,有效8例,总有效率86.96%,西沙必利组28例,显效17效,有效10例,总有效率96.4%,两组总有效率比较差异无统计学意义(P>0.05)。结论:多潘立酮与西沙必利治疗早产儿胃潴留疗效相当,且无明显不良反应发生,而西沙必利有引起严重心血管反应可能,故多潘立酮可作为治疗早产儿胃潴留首选。

Objective： To observe the clinical effects of domperidone and cisapride in treating gastric retention in premature infants.Methods： Fifty one tube-fed premature infants who were fit to the diagnostic criteria for gastric retention,were randomly grouped into domperidone group（0.3 mg/kg,per once） and cisapride group（0.2 mg/kg,per once）,infused 30 minutes before milk-fed,3 times per day for 5~7 days.Results： In the domperidone group,12 cases were obviously effective,8 cases were effective,3 cases were non-effective,and the total rate of efficiency amounted to 86.96%;in the domperidone group,the cases of obvious effect,present effect and non-effect were 17 cases,10 cases and 1 case,the total rate of efficiency was 96.4%.There was no statistically significant difference between the two groups（P0.05）.Conclusions： There is a similar effect for these two groups in treating premature infants,but according to the pharmacological effect,cisapride may cause serious cardiovascular reaction.In the treatment of gastric retention,domperidone could be the first choice in treating gastric retention in premature infants.