1Walsh-Sukys MC, Tyson JE, Wright LL, et al. Persistent pulmo- nary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes [ J]. Pediatrics. 2000, 105 ( 1 ) : 14.
2Pauvert O, Lugnier C, Keravis T, et al. Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery [ J ]. Br J Pharmacol, 2003, 139(3) : 513-522.
3van der Horst I, Morgan B, Eaton F, et al. Expression and func- tion of phosphodiesterases in nitrofen-induced congenital diaphragmatic hernia in rats [J]. Pediatric Pulmonology, 2010, 45 (4) : 320-325.
4Cruz-Blanquel A, Espinosa-Oropeza A, Romo-Hernandez G et al. Persistent pulmonary hypertension in the newborn: therapeu tic effect of sildenafil [J]. Proc West Pharmacol Soc, 2008, 51 73 -77.
5Baquero H, Soliz A, Neira F, et al. Oral sildenafil in infants with persistent pulmonary hypertension of the newborn : a pilot random- ized blinded study [J]. Pediatrics, 2006, 117(4) : 1077-1083.
6Juliana AE, Abbad FC. Severe persistent pulmonary hypertension of the newborn in a setting where limited resources exclude the use of inhaled nitric oxide: successful treatment with sildenafil I J 1. Eur J Pediatr, 2005, 164(10) : 626-629.
7Giuliano F, Jackson G, Montorsi F, et al. Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database [ J ]. International Journal of Clinical Practice, 2010, 64(2) : 240-255.
8Rossi R, Nuzzo A, Lattanzi A, et al. Sildenafil improves endothelial function in patients with pulmonary hypertension [ J ]. Pulm Phar- macol Ther, 2008, 21 ( 1 ) : 172-177.
9Li B, Yang L, Shen J, et al. The antiproliferative effect of silde- nafil on pulmonary artery smooth muscle ceils is mediated via upregulation of mitogen-activated protein kinase phosphatase-1 and degradation of extracellular signal-regulated kinase 1/2 phosphoryl- ation [J]. Anesthesia & Analgesia, 2007, 105(4): 1034.
10Takimoto E, Kass DA. Sildenafil's protective effect against cardiac hypertrophy [ J ]. Expert Rev Clin Pharmacol, 2009, 2 (4) : 323- 327.
5van der Horst I, Morgan B, Eaton F, et al. Expression and function of phosphodiesterases in nitrofen-induced congenital diaphragmatic hernia in rats[J]. Pediatr Pulmonol,2010,45 (4) : 320-325.
6Engelbrecht A. Sildenafil in the management of neonates with PPHN~ a rural regional hospital experience[J]. South Afr J Child Health, 2008,2(4) : 166-168.
8Sola A, Baquero H. Oral sildenafil in neonatal medicine:"tested in adults also used in neonates"[J]. An Pediatr (Barc),2007,66 (2) :167-176.
9Crosswhite P, Sun Z. Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension [ J ]. J Hypertens,2010,28(2) :201-212.
10Irene W.J.M.van der Horst,BeverlyMorgan,FarahEaton,IrwinReiss,DickTibboel,BernardThébaud.Expression and function of phosphodiesterases in nitrofen‐induced congenital diaphragmatic hernia in rats[J].Pediatr Pulmonol.2010(4)
