衍生化法合成高纯度顺式对叔丁基环己醇

Synthesis of high purity cis-4-tert-butylcyclohexanol by derivatization method

由对叔丁基苯酚催化加氢合成顺/反对叔丁基环己醇的混合物。用适量的叔丁基二甲基氯硅烷(TB-DMSCl)衍生化反应,得顺式对叔丁基环己醇的纯度可达99.5%以上。加氢反应条件实验表明,当浓盐酸加量为0.25 g、异丙醇为溶剂和温度70～80℃时反应效果最佳。根据衍生化数据对顺/反对叔丁基环己醇分离的反应机理进行了推测。

The cis/trans-4-tert-butyleyelohexanols were synthesized with 4-tert-butylphenol via catalytic hydrogenation. With appropriate amount tea-butyl dimethyl ehlorosilane（TBDMSC1）, more than 99. 5% purity of eis-4-tert-butyleyclohexanol could be obtained by derivatization method. The results of hydrogenation condition experiments showed the reaction effect was best when the amount of concentrated hydrachlorie acid was 0. 25 g,isopropanol as solvent and the reaction temperature was 70 -80 ℃. The reaetion mechanism of cis/trans-4-tert-butylcyclohexanols separation was speculated according to the defivatization data.