羊膜覆盖治疗高龄癌症患者化疗药外渗性溃疡

Human amnion membrane dressing the ulceration surface leaded from exosmotic chemotherapy drug in super-elder cancer patients:Therapeutic efficacy

目的探讨人胎鲜羊膜(以下简称羊膜)对癌症患者化疗药外渗性溃疡创面的治疗效果。方法将60例癌症化疗药外渗引起局部组织损伤致溃疡创面的患者随机分为试验组与对照组各30例,试验组采用羊膜进行创面覆盖治疗,对照组采用柏花香中药药液湿敷创面换药治疗,两组分别于24 h观察创面疼痛减轻情况和第3、7、14天上皮匍行后的面积及肉芽成熟程度,将两组创面愈合过程进行比较。结果经观察换药后24 h试验组的镇痛效果明显优于对照组;第3天肉芽及上皮组织生长两组无明显变化,第7、14天创面肉芽组织生长、上皮匍行速度试验组显著优于对照组(P<0.01)。结论羊膜具有很强的生肌作用,并能维持组织的生长、更新和修复,羊膜对癌症患者化疗外渗性溃疡创面具有良好的治疗效果。

Objective To explore therapeutic efficacy of the human amnion membrane on the ulceration leaded from exosmotic chemotherapy drug in super-elder cancer patients. Method The 60 super-elder cancer patients whose ulceration surface were leaded from exosmotic chemotherapy drug were randomly divided into trial group and control group （30 cases, each group）; the human amnion membrane was covered on the wound in trial group, the control group received traditional Chinese medicine liquid, BaiHuaXiang. The two groups were observed within 24 hours on the reduced degree of wound pain, and on mesothelial cells crawling area as well the maturity degree of granulation tissue on the 3rd, 7th, 14th days. The wound healing process were also observed. Result Analgesic efficacy within 24 hours in the trial group had more advantages than in control group; on the first three days in the maturity of the granulation tissue and epithelial ceils crawling velocity in the area between two groups there was no significant changes; on the first 7,14th days the maturity of the granulation tissue and epithelial cells crawling velocity in the area in the trial group had more advantages than in control group（P〈0.01）. Conclusion The human amnion membrane has a pivotal role in promoting muscle growth and maintaining the epithelial tissue growth, refine and repair, it also has a good therapeutic effect on the ulceration leaded from exosmotic chemotherapy drug in super-elder cancer patients.