中国西部地区321例癫痫患者预后的多因素分析

Prognostic multiple factors analysis of 321 patients with epilepsies in West China

目的观察新诊断癫痫患者经正规药物治疗1年的缓解率,探讨影响癫痫患者预后的因素。方法前瞻性研究2009年1～6月在华西医院新诊断的321例癫痫患者的预后。建立癫痫患者数据库,应用单因素卡方检验和多因素logistic回归分析判断癫痫患者预后的影响因素。结果治疗1年后本组患者的缓解率为51%。卡方检验分析显示,缓解组与未缓解组在年龄,病程,发作次数,文化程度,离院距离,发作类型,脑电图及头颅影像学检查结果方面有统计学差异。根据卡方检验分析结果,对发作次数,文化程度,离院距离,发作类型,脑电图及头颅影像学检查结果6个因素进行多因素logistic回归分析。结果显示入组前的发作次数大于5次,离院距离大于100km,头颅影像学检查结果阳性是预后的危险因素。结论癫痫患者预后与多种因素有关,针对上述危险因素进行预防,对于改善其预后具有重大的临床意义。

Objective To investigate the 1-year remission rate of newly diagnosed and treated epilepsy patients,as well as prognostic factors.Methods 321 newly diagnosed epilepsy patients were enrolled into our study during Jan.1 2009 to Jun.1 2009,and 1 year follow-up was conducted.Data base was built using Excel,univariate and Logistic regression statistics were used to analyze the prognostic factors.Results one-year remission rate was 51%.Between remission group and non-remission group,there was statistical difference in age,duration,seizure frequency,education level,distance from the hospital,seizure type,EEG and neuroimaging result.By logistic regression analysis,seizure frequency,distance from the hospital,neuroimaging results indicate poor prognosis.Conclusion The prognosis of patients with epilepsy have a variety of factors,prevent risk factors of great significance to improve the prognosis.