丝裂霉素膀胱内灌注治疗膀胱癌电切术后的疗效观察

TURBT in treatment of superficial bladder carcinoma

目的探讨经尿道电切术及术后使用丝裂霉素膀胱内灌注治疗浅表性膀胱肿瘤的临床疗效。方法对62例膀胱癌患者行经尿道膀胱肿瘤电切术,术后定期应用丝裂霉素膀胱内灌注化疗,并经7～72个月随访,观察膀胱肿瘤复发情况。结果 62例患者无肿瘤复发54例(87%),复发8例,均再行经尿道膀胱肿瘤电切术(TURBT)并继续丝裂霉素膀胱内灌注,未见全身药物不良反应,仅有3例膀胱灌注药物后出现短期轻度膀胱刺激症状。结论经尿道电切术治疗浅表性膀胱肿瘤具有手术简单、损伤小、出血少、恢复快、疗效好等优点。丝裂霉素膀胱内灌注能明显减少浅表性膀胱肿瘤的复发。

Objective To discuss the outcome of mitomycin C（MMC）after TURBT as a treatment of superficial bladder carcinoma.Methods 62 cases underwent TURBT and mitomycin C intravesical instillation were analyzed.Results All bladder carcinomas were a completely resection.Postoperation al1 the patients received mitomycin C（MMC） intravesical instillation.No one was recurrence in 54 cases after 7 to 72 months follow up（87%）,6 cases recurrence during 1 year,2 cases recurrence during 2 years.One case recurrence three times within 4 years.The patients received TURBT and mitomycin C intravesical instillation.Conclusion TURBT is less invasive,with clear visual field.definitive resection depth.and less recurrence in treatment of superficial bladder carcinoma.Mitomycin C intravesical instillation can significantly reduce superficial bladder cancer recurrence.