α-三氟甲基乙胺合成工艺研究

Study on Process for Producing α-Trifluoromethyl Ethylamine

以L-丙氨酸和四氟化硫为原料,压力下经一步氟化反应制得α-三氟甲基乙胺。实验研究获得的最佳工艺条件为：以100 g L-丙氨酸为原料,n（L-丙氨酸）∶n（四氟化硫）为1∶2,55℃及18-19 kgf/cm^2压力下保温反应12 h,产品收率在55%以上,产品盐酸盐熔点在218.5℃以上。

α-Trifluoromethyl ethylamine was prepared under pressure by using L-alanine and sulfur tetrafluoride as raw materials for one step fluoridation reaction.The optimal operating conditions for the process were investigated experimentally.These conditions obtained are： 100 g of L-alanine as raw material and molecular ratio of sulfur tetrafluoride to L-alanine at 2,the reaction at temperature of 55 ℃ and pressure of 18～19 kgf/cm^2 for 12 h.The yield of the product is above 55 % and the melting point of the hydrochloric salt of the product is above 218.5 ℃.