干细胞用于乳腺癌治疗的研究进展

Research Progress and Clinical Trials of Utilization of Stem Cells to Treat Breast Cancer

乳腺癌是女性最常见的恶性肿瘤之一,是一种严重影响女性身心健康甚至危及生命的恶性肿瘤,男性乳腺癌罕见。目前,乳腺癌的治疗仍以外科治疗为主。随着干细胞生物学的发展,人们发现造血干细胞移植在恶性肿瘤大剂量放、化疗后的造血重建和免疫重建中有着重要作用,而间充质干细胞可以作为基因载体而抑制肿瘤细胞的生长。这些研究为乳腺癌的治疗提供了全新的思路。分析目前人们应用干细胞治疗乳腺癌的研究现状,同时统计分析了中国临床试验注册中心数据库和美国clinicaltrials数据库中用干细胞治疗乳腺癌的临床试验的最新数据,并且指出了干细胞用于乳腺癌治疗的研究趋势,目的是为后续开展的用干细胞治疗乳腺癌的研究提供一定的参考。

Breast cancer is one of the most common malignancy women,which has serious impact on female health.Male breast cancer is rare.Breast cancer is usually treated with surgery and then possibly with chemotherapy or radiation,or both.Stem cells have been used for breast cancer treatment now.It has been reported that hematopoietic stem cell transplantation after high-dose radiotherapy or chemotherapy promotes hematopoietic reconstitution and immune reconstitution.In addition,mesenchymal stem cells can be used as gene carriers to suppress tumor cell growth.Here,we reviewed the researches of stem cell therapy for Breast Cancer and analyze the latest clinical trial data from Chinese Clinical Trial Registry and Clinical Trials,and show the future trends of utilization of stem cells to treat breast cancer.