摘要
现在普遍认为动脉粥样硬化(atherosclerosis,AS)是一种炎症,而单核/巨噬细胞的异常活动是引发这种炎症的关键因素,单核/巨噬细胞与AS发生和发展的各个阶段紧密相关。单核/巨噬细胞自身活动的相关领域以及它们在斑块部位与其他细胞的相互作用成为动脉粥样硬化新兴的治疗靶点。本文综述了从减少单核/巨噬细胞聚集、抑制氧化应激、调节巨噬细胞中的胆固醇代谢、减少巨噬细胞源性炎症反应、增加AS斑块稳定性等方面治疗AS的研究进展,旨在为抗动脉粥样硬化药物的临床使用和研究开发提供参考。
It is now generally recognized that atherosclerosis is an inflammatory disease, in which monocyte/macrophage plays a crucial role. The monocyte/macrophage is involved in every stage of atherosclerosis. The activity of monocyteJmacrophage and their interactions with other cells in the plaque mileu provide novel therapeutic targets for the treatment of atherosclerosis. This paper reviews the recent advances in the treatment of atherosclerosis from those aspects of reducing monocyte/macrophage, suppressing oxidative stress, regulating cholesterol metabolism involved in monocyte/macrophage activities, decreasing macrophage-derived inflammatory activity and increasing plaque stability, to provide a reference for anti-atherosclerosis drugs＇ clinical use, research and development.
出处
《生命的化学》
CAS
CSCD
北大核心
2011年第6期785-789,共5页
Chemistry of Life
关键词
单核/巨噬细胞
动脉粥样硬化
炎症因子
胆固醇代谢
氧化应激
Monocyte/macrophage
atherosclerosis
cholesterol metabolism
inflammatory factors
oxidative stress
