SREBP通过调节脂质代谢影响细胞生长

SREBPs affect cell growth by regulating lipid metabolism

固醇调节元件结合蛋白(sterol regulatory element binding protein,SREBP)属于核转录因子家族,是脂肪合成基因重要的转录调节因子,它在胆固醇调控中起重要作用。近年来,发现SREBP细胞的生长周期、增殖和衰老有着密切的联系。对SREBP功能的深入研究对进一步明确脂质代谢性疾病发病机制和细胞生长都有重要意义。

Sterol regulatory element binding proteins （SREBPs） belong to a family of the nuclear transcription factor, which are major transcription factors involved in biosynthesis of fat. SREBPs play an important role in the regulation of cholesterol. In recent years, many evidence has showed the close relationship between SREBPs and the cellular cycle, proliferation and aging. The deep study of the function of SREBPs is significant to further clarification of the pathogenesis of lipid disorders and cell growth,