色素上皮细胞源性因子的抗肿瘤活性

Anti-tumor effects of pigment epithelium-derived factor

色素上皮细胞源性因子(PEDF)是一种最早从人类胚胎视网膜色素上皮中发现的相对分子质量约为50 KDa的分泌糖蛋白。PEDF广泛存在于人体内多个器官和组织中,表达量与人体内多项病理生理过程密切相关。最近研究表明,PEDF在肿瘤的生长、侵袭和转移过程中发挥着重要作用。肿瘤组织中的微血管密度与肿瘤的生长速度呈正相关,作为目前已知的最强的内源性血管生成抑制因子,PEDF能够通过抑制肿瘤血管生成而抑制肿瘤的生长。此外,PEDF亦能通过激活多种复杂信号转导通路诱导肿瘤细胞的凋亡。

PEDF is a 50-kDa secreted glycoprotein first discovered as a factor secreted by the retina pigmented epithelium of the human foetal eye. PEDF is widely spread in human tissues and organs, and its expression is related to the fi, mction of human body. Recent studies have shown that PEDF plays an important role in tumor growth, invasion, and metastasis. As we know, microvessel density is correlated with the rapid growth of tumor cells. As the most potent endogenous angiogenesis inhibitor, PEDF can suppress tumor growth by inhibiting angiogenesis. In addition, PEDF can also induce apoptosis through activating complex signal transduction pathways.