摘要
研究证实,细胞的运动、迁徙与肿瘤转移密切相关,尤其是细胞伪足的参与。I-BAR(Inverse Bin-Amphiphysin-Rvs)蛋白质家族因共有一段高度保守的I-BAR结构域而得名,具有结合肌动蛋白、细胞膜和小GTP酶的特点。目前的研究认为,I-BAR蛋白质家族参与细胞膜结构重塑,与细胞伪足的形成有关。I-BAR蛋白质家族介导细胞产生伪足的经典途径为Rho家族GTP酶结合到I-BAR等功能域,使活化的I-BAR蛋白质家族成员激WASP(Wiskott-Aldrich syndrome protein)和WAVE/Scar(WASP familyverprolin homologous protein)蛋白质家族,从而引发Arp2/3(actin related proteins 2 and 3)复合物介导的肌动蛋白成核和聚合反应。
It is reported that cell movement and migration, particularly the involvement of pseudopodia are contributed to tumor metastasis. The I-BAR family plays a central role in membrane protrusion, which is the basic structure of pseudopod. Rho-family GTPases bind to and activate I-BAR. Then the activated I-BAR could trigger WASP （Wiskott-Aldrich Syndrome protein） and WAVE/Scar （WASP family verprolin homologous protein） family protein, and then they trigger the actin nucleation and polymerization mediated by Arp2/3 （actin related proteins 2 and 3） complex.
出处
《生命的化学》
CAS
CSCD
北大核心
2011年第6期891-895,共5页
Chemistry of Life
