Asc11与成纤维细胞转化为功能性神经元的关系

Relationship between Ascll and the convertion of fibroblasts into functional neurons

神经母细胞特异性转移因子抗原(Achaete-scute homolog 1 Ascl1)是一种重要的转录调节因子,联合Brn2[也称作Pou3f2(POU domain,class 3,transcription factor 2)]、Mytll(myelin transcription factor 1 like)等转录因子迅速有效地将成纤维细胞转化为功能性神经元,而无需将成纤维细胞逆转成胚胎状态。从非神经系统生成诱导性神经细胞可能对神经系统发育、神经系统疾病模型和再生医学的研究具有重要意义。

Ascll （Achaete-scute homolog L） is an important transcriptional regulator, which can rapidly and efficiently covert fibroblasts into functional neurons, without reversing into embryonic fibroblasts state, by binding itself to Brn2 （also known as Pou3f2） and Mytl 1. Generation of induced neuronal cells from non-neural iineages could have significance for studies of neural development, neurological disease modeling, and regenerative medicine.