N-末端B型脑钠肽前体与糖尿病肾病的相关性被引量：1

Correlation of N-terminal-pro-B-type natriuretic peptide and diabetic neohropathy

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摘要目的探讨N-末端B型脑钠肽前体(NT-pro-BNP)与糖尿病肾病(DN)的关系。方法选取2型糖尿病(T2DM)患者88例,并根据血肌酐(Scr)、尿微量白蛋白排泄率(UAER)分为肾功能不全的DN组(A组,20例)、肾功能正常而有大量蛋白尿的DN组(B组,18例)、仅有微量白蛋白尿的DN组(C组,25例)、非DN患者的T2DM组(D组,25例)及非T2DM的正常对照组(E组,28例),采用电化学发光法检测各组血浆NT-pro-BNP水平。结果 A、B、C、D、E组血浆NT-pro-BNP水平依次递减,并有统计学意义(P<0.05)。结论 DN患者的血浆NT-pro-BNP水平显著升高,且随肾功能损害的加重逐级升高,在DN的发生、发展过程中起重要作用。 Objective To explore the relationship between N-terminal-pro-B-type natriuretic peptide and diabetic nephropathy.Methods Selected 88 T2DM patients,according to patients＇ Ser,UARE,were divided into renal insufficiency DN group（group A,20 cases）,DN group with normal renal function and large proteinuria（group B,18 cases）,DN group with Microalbuminuria（group C,25 cases）,T2DM group（group D,25 cases） and control group（group E,28 cases）.Electrochemiluminescence assay was performed to measure the level of plasma NT-pro-BNP.Results The level of plasma NT-pro-BNP of group A,B,C,D,E gradually decreasing,and there were statistical differences.Conclusions The level of plasma NT-pro-BNP in DN patients increased significantly,and with renal damage gradually increased,it is important in the process of development of DN.

作者陆玉莲姚伟峰

机构地区无锡市第二人民医院内分泌科

出处《医药论坛杂志》 2011年第22期9-11,共3页 Journal of Medical Forum

关键词 N-末端B型脑钠肽前体 2型糖尿病糖尿病肾病尿微量白蛋白排泄率 NT-pro-BNP T2DM DN UARE

分类号 R587.2 [医药卫生—内分泌]

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