太宁栓结合生物反馈治疗出口梗阻性便秘40例临床观察

Clinical observation on patients with outlet obstructive constipation treated by titanoreine combined with biofeedback 40 cases

目的本肛肠病治疗中心自2009年6月至2010年6月运用外用太宁栓结合生物反馈治疗了出口梗阻性便秘患者40例。方法可明显改善排便困难、便干、肛门下坠不适等症状,明显减少口服泻药和灌肠的次数,总有效率为71%,无副作用。结果治疗前后应用肛门测压、盆底肌电图的检查结果进行量化对照发现,治疗后直肠容量感觉阈值高于治疗前(P<0.05),治疗后肛管静息压和收缩压均明显低于治疗前(P<0.01),治疗后患者肛管随意肌(耻骨直肠肌、外括约肌)肌电活动的迟缓系数明显降低(P<0.05),直肠最低感知量、排便感知量、最大耐受量明显增加(P<0.05)。结论外用太宁栓结合生物反馈治疗出口梗阻性便秘疗效确切、稳定,值得进一步推广。

Objective Our anorectal diseases treatment centre had treated 40 patients with outlet obstructive constipation treated by Titanoreine combined with biofeedback from June 2009 to June 2010.Methods The results showed that this treatment could statistically improve defecate difficulty,dry stool,anus falling and bulge et al,and reduce orally cathartic and enteroclys times,the effective rate was 71%.This treatment had no side effects.Results The results of anorectal manometry and pelvic floor electromyography before and after treatment showed that after the treatment rectum capacity threshold increased（P0.05）,anal resting and systolic pressure was obviously lower than that of before treatment（P0.01）,bradytelic coefficient of analcanal voluntary muscle（puborectalis,external sphincter） myoelectric activity was obviously lower（P0.05）,rectum minimum appreciable amount,defecate appreciable amount,maximum tolerance amount obviously increased（P0.05）.Conclusions The treatment of Titanoreine combined with biofeedback on outlet obstructive constipation has exact effect and is worthy to be popularized.