阿德福韦酯耐药后慢性乙型肝炎患者的抗病毒治疗

Clinical analysis of Adefovir dipivoxil combined with interferon in treatment of chronic hepatitis B 66 cases

目的比较阿德福韦酯、干扰素(IFN)联用与干扰素单用治疗慢性乙肝的疗效。方法选择慢性乙肝患者66例,分为联合治疗组33例,干扰素组33例。以谷丙转氨酶(ALT)、乙肝五项、乙肝病毒DNA(HBV DNA)为观察指标,比较不同治疗方案对指标的影响。结果治疗12个月,联合治疗组与干扰素组对慢性乙肝患者血清HBeAg/抗HBeAg转换率分别为48.48%和30.30%(χ2=2.22,P>0.05);对慢性乙肝患者血清HBV DNA的阴转率分别为75.8%和33.33%(χ2=7.22,P<0.01)。结论阿德福韦酯与干扰素联合使用有协同作用,其抗病毒治疗效果优于单用干扰素组。

Objective To compare the efficacy of adefovir dipivoxil,interferon（IFN） in conjunction with the with interferon alone in treatment of chronic hepatitis B.Methods Totally 66 cases of chronic hepatitis B patients were divided into combined treatment group 33 cases,interferon group of 33 cases.With alanine aminotransferase（ALT）,hepatitis B five items,hepatitis B virus DNA（HBV DNA） to observe the indicator to compare different treatment programs for indicators.Results After 12 months,the combination therapy group and the interferon group of patients with chronic hepatitis B HBeAg / anti-HBeAg conversion rates were 48.48% and 30.30%（χ2=2.22,P0.05）;of serum HBV DNA in patients with chronic hepatitis B Yam transfer rates were 75.8% and 33.33%（χ2=7.22,P0.01）.Conclusions Adefovir dipivoxil combined with interferon use of synergies,its anti-viral therapy more effective than interferon alone group.