C-反应蛋白在慢性肾衰维持性血液透析患者中的表达

Clinical significance of expression of C-reactive protein in chronic renal failure in hemodialysis patients

目的探讨C-反应蛋白在慢性肾衰维持性血液透析患者中的表达及临床意义。方法对患者进行透极每周2～3次,每次4h。结果血液透析患者Hb、ALB水平降低,而Scr水平显着增高,与对照组比较差异有显著性(P<0.05),血液透析可显着降低外周血Scr水平,但却可诱导CRP水平增高。结论动态监测尿毒症患者的CRP有助于及早发现患者的潜在危险因素,早期控制微炎症状态、纠正贫血、改善营养不良,对延长维持性透析患者的生存时间、提高生存率有临床指导作用。

Objective To investigate the expression and clinical significance of C-reactive protein in chronic renal failure in hemodialysis patients.Methods All patients underwent hemodialysis 2~3 times every week,4 hour at a time.Results Hemodialysis patients with Hb,ALB level decreased,and Scr levels significantly higher,compared with the control group the difference was significant（P〈0.05）,hemodialysis can significantly reduce blood Scr level,but can induce CRP levels increased.Conclusions Dynamic monitoring of CRP in patients with uremia patients help us to potential early detection of risk factors,early control of micro-inflammatory state,to correct anemia,improve nutrition,to extend the maintenance dialysis patient＇s survival time and improve the survival rate with clinical guidance role.