恶性胸腔积液不同热化疗灌注模式的疗效比较

Comparison of different model for pleural hyperthermic chemoperfusion

目的:探讨最佳胸腔热化疗灌注模式。方法:49例合并恶性胸腔积液的肺癌患者接受了胸腔热化疗灌注,依治疗模式分为手术组(手术切除病变,术后连续灌注),循环灌注组(胸腔闭式引流术,术后循环灌注)和非循环灌注组(胸腔穿刺术,术后保留灌注后持续引流)。比较不同组别的治疗效果。结果:手术组18例胸腔积液全部得到控制,循环灌注组及非循环灌注组中各有1例(1/8),7例(7/23)未控,治疗所需时间分别为(5.56±1.01)天,(8.8±2.32)天和(9.86±5.88)天。结论:胸腔内热化疗灌注的治疗模式以手术切除病变后连续循环灌注为佳。

Objective：To explore the optimal strategy of pleural hyperthermic chemoperfusion.Methods： All 49 patients of lung cancer with malignant pleural effusions who underwent pleural hyperthermic chemoperfusion were divided into operation group（lesion resection and continual perfusion）,circular perfusion group（thoracic drainage and circular perfusion） and non-circulating perfusion group（thoracentesis,retention perfusion then drainage）.Their therapeutic effects were compared.Results：Pleural effusion in operation group were all controlled within 5.56±1.01 days,while 1 in circular group（1/8） and 7 in non-circulating perfusion group（7/23） failed.The average time needed for effusion controlling were 8.8±2.32 and 9.86±5.88 days in the later two groups.Conclusion： Continual and circular perfusion following operation is the recommended model of pleural hyperthermic perfusion chemotherapy.