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乙酰辅酶A羧化酶与恶性肿瘤相关性的研究进展 被引量:3

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摘要 乙酰辅酶A羧化酶(acetyl coacarboxylase,ACC)是脂肪酸合成过程中的关键酶,它催化脂肪酸合成的第一步反应,即ACC合成丙二酰辅酶A,然后丙二酰辅酶A在脂肪酸碳链延长酶系作用下合成长链脂肪酸。目前研究发现,脂肪形成在促进癌细胞存活中起着重要的作用,脂肪酸合成的激活被认为是癌细胞的一个特性。因此,ACC可能成为肿瘤治疗的新靶点,本文就近年来ACC与肿瘤的相关性研究作一综述。
作者 李妹 狄文
出处 《上海医学》 CAS CSCD 北大核心 2011年第11期897-900,共4页 Shanghai Medical Journal
基金 上海市科学技术委员会(学科带头人 08XD14027) 上海交通大学医学院博士创新基金 上海市教育委员会重点学科 上海市妇科肿瘤重点实验室(09dz2200300)资助项目
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