胺碘酮对扩张型心肌病伴慢性心力衰竭患者心功能的影响

Amiodarone influence cardiac function of dilated cardiomyopathy patients with chronic heart failure

目的探讨胺碘酮对扩张型心肌病伴慢性心力衰竭患者心功能的影响。方法收集了健康对照组30名,心力衰竭组67例(入组前已经进行了常规治疗),根据是否服用胺碘酮片分为心力衰竭1组30例、心力衰竭2组37例,4周后结束治疗,进行统计分析各组患者治疗前后的C反应蛋白(CRP)以及左室舒张末期直径(LVDD,mm)、左室射血分数(LVEF,%)。结果①健康对照组和心力衰竭组在LVDD、LVEF以及CRP含量上差异有统计学意义(P均<0.01)。②心力衰竭1组经过常规治疗和胺碘酮4周治疗后与入组时进行对比,CRP值有所降低,差异有统计学意义(P<0.01);LVEF值较治疗前有所升高,差异有统计学意义(P<0.01)。③心力衰竭2组经过常规治疗4周后与入组时进行对比,CRP值、LVDD、LVEF差异无统计学意义(P>0.01)。结论对于伴有慢性心功能不全的扩张型心肌病患者给予胺碘酮治疗,可以减少CRP的产生,减少相关的炎症反应,改善心功能,进而可能提高患者的生存率。

Objective To invcstigatie the effect of amiodarone to cardiac function of patients with dilated cardiomyo-pathy and chronic heart failure. Methods Collected the normal control group （n=30）, chronic heart failure group （n=67） which were divided into 2 groups based on whether or not amiodarone was included in their treatment （amiodarone group： n=30; no amiodarone group： n=37）. After four week＇ treatment, each patients＇ C-reactive protein （CRP） levels and left ventricular end-diastolic （LVDD, mm） in diameter, left ventricular ejection fraction （LVEF, %） were tested and anal-yzed statistically before and after treatment. Results ①There was obvious difference about the content of LVDD,LVEF and CRP between normal control group and chronic heart failure group （P〈0.01）. ② There was difference statistically about the content of CRP compared with the previous which descended from the group treated by amiodarone（P〈0.O1 ）; the value of LVEF compared with the previous was increased in the same group（P〈0.01 ）.③ There was no difference statistically about the value of CRP, LVDD and LVEF compared with the previous from the group which had no amiodarone treated after 4 weeks （P〉0.01）. Conclusion For dilated cardiomyopathy patients with chronic heart failure,amiodarone treatment could reduce the generation of CRP, reduce the inflammation associated, improve heart function and improve patient survival rates.