摘要
目的:研究布洛芬口腔崩解片的溶出介质,建立高效液相色谱法测定布洛芬口腔崩解片的溶出度。方法:以磷酸盐缓冲液(pH=7.2)900mL为溶出介质,桨法,转速为75rpm,30min时取样,取样后采用HPLC法测定。结果:布洛芬在74.92～174.82μg/mL的范围内呈现良好的线性关系(r=0.9998),其平均回收率为98.6%(RSD=0.3%),溶出曲线表明在30min内,布洛芬溶出度可达75%以上,限度为80%。结论:3批样品的溶出度均符合规定。
Objective：To study the Orally disintegrating tablet of ibuprofen dissolution media, the establishment of high performance liquid chromatography of ibuprofen orally disintegrating tablets dissolution. Methods：With phosphate buffer （pH = 7. 2） 900mL as dissolution medium, oar method, rotation speed 75rpm, 30min for the sampling, the sampling method used after HPLC. Results：Ibuprofen in the range of 74.92 - 174.82μg/mL showed a good linear relationship （r= 0. 9998）, the average recovery was 98.6% （RSD=0.3%）, Dissolution curves show that： in 30min, the ibuprofen dissolution of up to 75%, 80% limit. Conclusion：3 batches of samples were found to be dissolution.
出处
《亚太传统医药》
2012年第1期48-49,共2页
Asia-Pacific Traditional Medicine
关键词
布洛芬
口腔崩解片
溶出度
溶出曲线
Ibuprofen
Orally Disintegrating Tablet
Dissolution
Dissolution Curve
