柴胡溶石颗粒治疗胆石症临床研究

A Clinical Study on Treating Cholelithiasis with Chaihurongshi Granules

目的:观察柴胡溶石颗粒治疗胆石症的临床疗效。方法:根据中药新药临床研究指导原则,对120例胆石症患者,中医辨证为肝郁气滞证,用柴胡溶石颗粒与胆石利通片进行临床比较。结果:治疗组痊愈26例(43.33%),显效25例(41.67%),有效6例(10.00)%),无效3例(5.00%),总有效率为95.00%;对照组痊愈13例(21.67%),显效21例(35.00%),有效18例(30.00%),无效8例(13.33%),总有效率86.67%,两组差异具有显著性意义(P<0.01)。两组治疗前后证候积分变化情况比较,与治疗前比较,治疗组有非常显著性差异(P<0.01),对照组有非常显著性差异(P<0.01);与对照组比较有非常显著性差异(P<0.01)。不同部位排石有效率比较,均有非常显著性差异(P<0.01)。结论:柴胡溶石颗粒治疗胆石症疗效显著。

Objective： The therapeutic effectiveness of Chaihurongshi granules on Cholelithiasis was studied. Methods： According to the guideline for the clinical study of traditional Chinese drugs ,We compared the effectiveness of chaihurongshi granules and Danshilitong tablets used for 120 cases with cholelithiasis that diagnosis according to an overall difference of symptoms and signs was liv erqi stagnation syndrome. Results： After treatment, 26 （43. 33 %） patients were cured , 25 （41.67 %） obvious effective, 6 （ 10. 00 %） effective ,3（5.00） ineffective in the treatment group ;the total effective rate being 95.00 % . In the control group , 13 （21. 67 % ） patients were cured ,21 （35.00 %） markedly effective , 18（30.00%） effective ,8 （13.33 %） ineffective; the total effective rate being 86.67 %. There was significant differences of effective rate between the two groups （P〈 0.01 ）. There were significant differences in the scores of the clinical symptoms and the signs of the patients before and after treatment in the control group （P〈 0.01） and in the treatment group （P〈0.01） . There were significant difference in the scores of the clinical symptoms and the signs of the patients between the two groups after treatment （P〈0 01） . There was significant difference in the rate of removing cholelithiasis between the two groups （P〈0.01）. Conclusion. Chaihurongshi granules had notable curative effect for treating Cholelithiasis.