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铜绿假单胞菌中群体感应系统的研究进展 被引量：8

Research progress of quorum sensing in Pseudomonas aeruginosa
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摘要 群体感应系统(quorum sensing)是一种细菌细胞与细胞间的信号传递系统。细菌通过可扩散的小分子信号分子感知细胞群体的密度,从而引起一些特定基因在细菌群体中的协调表达。铜绿假单胞菌中的QS系统包括LasI/LasR和RhlI/RhlR两条主要的信号系统和喹诺酮信号系统。本文系统地介绍了铜绿假单胞菌中QS系统的研究现状和相关应用。 Quorum sensing is a kind of signaling pathway for communication among bacteria cells. Bacteria can monitor their population density and regulate hunderds of genes expression by detecting small diffusible molecules. The P aeruginosa quorum sensing circuitry, is comprised of two complete systems （LasR/LasI and RhlI/RhlR） and one orphan 4-quinolone signalling system. This paper reviews the regulation mechanism and it＇s potential application of quorum sensing systems of P. aeruginosa.
作者 杨帆 张乐 盛哈蕾 张克斌
机构地区 第三军医大学新桥医院实验技术中心
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2012年第1期16-20,共5页 Chinese Journal of Antibiotics
基金 国家自然科学基金(30970115)
关键词 铜绿假单胞菌 群体感应 毒力因子 Pseudomonas aeruginosa Quorum sensing Virulence factor
分类号 R378.991 [医药卫生—病原生物学]
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参考文献50

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同被引文献96

  • 1李蒙英,陆鹏,张迹,许敬亮,李顺鹏.生物膜中群体感应因子细菌的分离及成膜能力[J].中国环境科学,2007,27(2):194-198. 被引量：10
  • 2郭嘉亮,陈卫民.细菌群体感应信号分子与抑制剂研究进展[J].生命科学,2007,19(2):224-232. 被引量：31
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中国抗生素杂志
2012年 第1期

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