小分子CCR5拮抗剂研究进展

Progress in the Research of Small Molecule CCR5 Antagonists

趋化因子受体5(CCR5)是HIV-1侵入宿主细胞的主要辅助受体之一。目前已发现许多小分子CCR5拮抗剂,其中一些化合物已进入临床研究和应用。本文介绍了小分子CCR5拮抗剂的作用机制,综述了近几年来各种不同结构类型的小分子CCR5拮抗剂的研究进展。

C-C chemokine receptor type 5 （CCR5） has been recognized as a major co-receptor in the HIV-1 entry process. Currently, many kinds of novel small molecule CCR5 antagonists for the treatment of AIDS have been identified and progressed into clinical trials. In this article, after brief introduction of the mechanism of action, current progress in drug research for various small molecule CCR5 antagonists is reviewed.