高压氧对急性脑梗死患者血清C-反应蛋白及白细胞介素6水平的影响

Effect of the hyperbaric oxygen （HBO） on the level of serum CRP and IL -6 in patients with acute cerebral infarction

目的探讨高压氧治疗对急性脑梗死患者血清c-反应蛋白（CRP）及白细胞介素6（IL-6）的水平和病情的影响。方法选择80例脑梗死患者，随机分为常规治疗组和高压氧治疗组，两组患者治疗14d后进行血清CRP和IL-6测定，并进行神经功能缺损评分比较。结果两组患者治疗后血清CRP和IL-6水平以及神经功能缺损评分与治疗前比较均显著下降（P〈0．05）；高压氧治疗组较常规治疗组下降更为显著，差异有统计学意义（P〈0．05）结论高压氧能显著降低脑梗死患者血清CRP和IL-6水平，改善神经功能缺损程度，值得临床推广应用。

Objective To study the effect of C - reactive protein（CRP） and IL - 6 in patients with hyperbaric oxygen （HBO） on the level of serum acute cerebral infarction. Methods Eighty patients with cerebral infarction were randomly divided into HBO treatment group and general treatment group, the serum CRP and IL- 6 was tested and the neurological impairment score（NDS） was evaluated after 14 days treatment by HBO. Results The levels of serum CRP and IL -6 and NDS in two groups were decreased after treatment （P 〈 0.05）. But the levels of CRP, IL - 6 and NDS in HBO group decreased more obviously after treatment, compared with general treatment group （P 〈 0.05 ）. Conclusions HBO may reduce tho levels of CRP and IL - 6, relieve the neurological impairment of patients with cerebral infraction, and deserve further clinical application.