2型糖尿病初诊冠心病患者冠状动脉造影特点分析

Clincal characteristic analysis of newly diagnosed coronary heart disease by cornary angiography in type 2 diabetic patients

目的探讨2型糖尿病初诊冠心病患者（CHD）的冠状动脉病变特点及其与血糖、血脂的相关性。方法采用回顾性研究，对126例入我院就诊并经冠状动脉造影检查初次确诊为冠心病患者，按患者血糖水平分为糖尿病冠心病组及非糖尿病冠心病组，测空腹血糖、糖化血红蛋白、低密度脂蛋白、高密度脂蛋白、胆固醇、甘油三脂，比较两组间生化检查的结果，分析两组间冠状动脉病变特点。结果糖尿病组冠状动脉重度病变占83．3％，弥漫性病变占43．3％，较非糖尿病组的58．1％与13．4％明显升高，差异有统计学意义；糖尿病组2支及2支以上病变发病率为共79．9％，较非糖尿病组51．3％明显升高，差异有统计学意义；生化结果显示糖尿病组患者空腹血糖、糖化血红蛋白、低密度脂蛋白、甘油三脂较非糖尿病组均明显升高，高密度脂蛋白则明显降低，差异有统计学意义；胆固醇两组间比较差异无统计学意义。结论糖尿病合并冠心病患者冠状动脉病变较重，病变部位较弥漫；糖尿病是发生冠心病的独立危险因素。

Objective To investigate the main clincal characteristics of coronary angiograph and relation with clinical characteristics of conoary angiograph and relation with fasting plasma glucose （FPG）, glycosylated hemoglobin （ HbAlc ）, low density lipoprein （ LDL - C ）, high density lipoprein （ HDL - C ）, triglyceride （TG） and cholesterol （ TC ） in newly diagnosed coronary heart disease （ CHD ）. Methods One hundred and twenty - six CHD patients by undergoing coronary angiography from our hospital were retrospectively analyzed and then all the patients were devided into type 2 diabetes group and no diabetes patient group by blood glucose level. FPG, HbAlc, TG, TC were detected in all subject. The clinical features and data from coronary angiographies were compared. Results It was revealed that the incidence rate of severe coronary stenosis was 83.3% and diffuse lession was 43.3% in type 2 diabetic patients, which were increased than that of non - diabetic patients. The levels of FPG, HbAI c, TG, TC were significantly higher in diabetes group than those in non - diabetes group. The difference of TG in two group existed, but it was not statistical significant. Conclusions The significant degree of coronary artery disease is light in type 2 diabetic patient. Diabetes is one of risk factors for CHD.