肌红蛋白、肌酸激酶同工酶和心肌肌钙蛋白联合检测在急性心肌梗死早期诊断的临床意义

Clinical significance of myoglobin combined with MB isoenzyme of creatine kinase and cardiac troponin I in the early diagnosis of acute myocardial infarction

目的初步探讨心肌酶谱和肌钙蛋白联合检测在急性心肌梗死（AMI）早期诊断的临床意义。方法对遂川县人民医院2008年1月至2011年1月就诊的120例急性胸痛患者，采集静脉血联合检测肌红蛋白（MB）、肌酸激酶同工酶（CK—MB）和心肌肌钙蛋白I（cTnI），并进行统计学分析。结果120例急性胸痛患者中63例确诊为AMI，急性心肌梗死组血清MB、CK—MB和cTnI含量显著高于对照组，差异有统计学意义。结论MB、CK—MB和cTnI的联合应用有助于AMI早期的快速诊断和鉴别诊断，具有重要的临床意义。

Objective To investigate the clinical significance of myoglobin （MB） combined with creatine kinase isoenzyme MB（ CK- MB） and cardiac troponin I （cTnI） in the early diagnosis of acute myoardial infarction. Methods One hundred and twenty patients with acute chest pain hospitalized from January 2008 to January 2011 in our department were included the study. Venous blood was draw from all patients. Then MB, CK -MB and cTnI were detected. Sixty healthy individuals were selected as controls. All data were analysed statistically by SPSS 12.0. Results The MB, CK - MB and cTnI levels in AMI patients were all significantly higher than those in control group （ P 〈 0.05 ）. Conclusions Myoglobin combined with creatine kinase isoenzyme MB and cardiac troponin I is helpful to the early diagnosis of acute myocardial infarction, which has important clinical significance.