前列地尔对急性脑梗死患者血清蛋白SIOOB和基质金属蛋白酶-9的影响

Effect of alprostadil on the S100B and MMP -9 in serum of patients with acute cerebral infarction

目的探讨前列地尔对急性脑梗死患者血清蛋白S100B（S100B）和基质金属蛋白酶9（MMP-9）的影响。方法将60例急性脑梗死患者随机分为对照组和治疗组，对照组采用常规治疗，治疗组采用常规治疗联合前列地尔治疗，疗程均为14d。治疗前后测定血清S100B和MMP-9。结果对照组S100B和MMP-9的治疗后分别为（0．71±0．27）ug/L和（281±95）ug／L，治疗组治疗后分别为（0．46±0．22）ug/L和（206±74）ug/L。两组治疗后SIOOB和MMP-9的表达明显少于治疗前，并且治疗组优于对照组。结论前列地尔明显改善急性脑梗死患者血清S100B和MMP-9的表达，值得进一步推广。

Objective To study the the effect of alprostadil on the S100B and MMP -9 in serum of patients with acute cerebral infarction. Methods Sixty patients were randomly divided into two groups, the control group （ n = 30） and the treatment group （ n = 30）. The control group was given routine treatment, the treatment group was given alprostadil beside routine treatment. Alprostadil for 14 days. The S100B and MMP -9 in serum were tested before and after treatment. Results The S100B and MMP- 9 in control group was（0.71 ±0.27）wg/L and （281 ±95）ug/L. The S100B and MMP-9 in treatment group was （0.46 ±0.22）ug/L and （206 ±74）ug/L. After treatment, the level of s100B and MMP- 9 expression decreased than that before treatment, and the effect in treatment group was better than that in control group. Conclusions Alprostadil could decrease the S100B and MMP -9 in acute cerebral infarction, which was worth promotion.