2种药物方案治疗小儿抗菌药相关性肠炎的疗效观察

Efficacy Observation of Different Drugs in the Treatment of Children with Antibiotic-associated Enteritis

目的:观察不同药物治疗小儿抗菌药相关性肠炎的临床疗效。方法:将我院就诊的86例小儿抗菌药相关性肠炎患儿随机分为2组,对照组42例采用口服甲硝唑、蒙脱石散治疗;观察组44例采用甲硝唑、蒙脱石散、乳酸菌素片保留灌肠治疗(甲硝唑及蒙脱石散用法用量同对照组;乳酸菌素片根据患儿情况0.4～1.2g保留灌肠,bid),2组疗程均为7～10d,治疗后比较2组的临床治疗效果。结果:观察组的总有效率为97.8%,明显高于对照组(81.0%),2组比较差异有统计学意义(P<0.05);观察组的不良反应发生率为4.5%,略低于对照组(9.5%,P>0.05)。结论:与对照组比较,甲硝唑、蒙脱石散、乳酸菌素片方案治疗小儿抗菌药相关性肠炎疗效较好,且不良反应发生率低。但临床应用时应根据患儿病情选择适合的治疗药物及治疗方式。

OBJECTIVE： To observe the effect of different drugs in the treatment of children with antibiotic-associated enteritis. METHODS： In our hospital, 86 children with antibiotic-associated enteritis were randomly divided into 2 groups, the control group （42 cases） were treated with oral Metronidazole and Montmorillonite powder treatment, the observation group （44 cases） were treated with Metronidazole, Montmorillonite powder and Lactein Tablets（0.4~l.2 g, bid）.Both group were treated 7~10 d. The clinical results of 2 groups were compared. RESULTS： The total effective rate of the observation group was 97.8%, significantly higher than 81.0% of the control group, the difference was statistically significant between 2 groups （P〈0.05） ; the adverse reac- tions of the observation group was 4.5%, slightly lower than 9.5% of the control group, there was no significant difference be- tween 2 groups （P〉0.05）. CONCLUSIONS： Compared with control group, Metronidazole, Montmorillonite powder and Lactein tablets in treatment of children with antibiotic-associated enteritis has good efficacy and low adverse reaction, but should choose suitable treatment in clinical according to the children＇s condition.