甲亢患者口服碳酸锂后甲状腺摄碘率变化的Meta分析

Changes of Iodine Uptake Rate of Thyroid in Hyperthyroid Patients after Oral Administration of Lithium Carbonate: A Meta-analysis

目的:系统评价口服碳酸锂对甲状腺亢进(以下简称甲亢)患者甲状腺摄碘率的影响。方法:计算机检索PubMed、EM-Base、Cochrane、中国期刊网和中国生物医学文献数据库,辅以Google网络检索和手工检索,对纳入的研究采用RevMan5.1软件进行Meta分析。结果:共纳入5项2003-2009年发表的关于口服碳酸锂对甲亢患者甲状腺摄碘率影响的研究,合计135例患者。Meta分析结果显示,口服碳酸锂后甲状腺2h[WMD=-13.38,95%C(I-14.90,-11.85),P<0.00001]、4h[WMD=-16.74,95%CI(-26.58,-6.90),P=0.0009]、6h[WMD=-19.96,95%CI(-23.38,-16.55),P<0.00001]、24h[WMD=-20.62,95%C(I-24.95,-16.29),P<0.00001]摄碘率明显高于服药前,且差异有统计学意义。结论:口服碳酸锂可用于部分甲状腺摄碘率低的甲亢患者。

OBJECTIVE： To evaluate the effect of lithium carbonate on radioactive iodine uptake rate of thyroid in hyperthy- roidism patients with oral administration. METHODS： The pertinent literatures were retrieved from PubMed, EMBase, Cochrane, CNKI, CBM and other databases, accompanying with Google and manual retrieval. A Meta-analysis of the data was conducted by Rev Man 5.1 software. RESULTS： A total of 5 trials published during 2003--2009 were included, involving 135 hyperthyroidism patients. Results of Meta-analysis showed that the uptake rate of radioactive iodine in hyperthyroidism patients increased significant- ly after taking lithium carbonate orally 2 h[WMD= - 13.38, 95%CI（ - 14.90, - 11.85） ,P〈0.000 01],4 h[WMD=- 16.74,95% CI（--26.58, -6.90）,P=0.000 9],6 h[WMD=-19.96,95%CI（--23.38, --16.55）,P〈0.000 01],24 h[WMD=-20.62,95%CI （-24.95, -16.29）,P〈0.000 01]. There was statistical significance. CONCLUSION： Oral administration of lithium carbonate is suitable for some hyperthyroidism patients who has low radioactive iodine uptake rate of thyroid.