血脂正常原发性高血压患者微量白蛋白尿与颈动脉粥样硬化的关系

Relationship between microalbuminuria level and carotid atherosclerosis in patients with hypertension and normal blood lipid

目的探讨血脂正常的原发性高血压患者微量白蛋白尿与颈动脉粥样硬化(carotid atherosclerosis,CAS)的关系。方法血脂正常的原发性高血压患者169例,行颈动脉彩色多普勒超声检查,测量左、右颈动脉内膜-中层厚度,根据测量结果分为斑块组92例与无斑块组77例,将CAS分为0-4级并检测尿微量白蛋白水平。结果斑块组尿微量白蛋白水平高于无斑块组(P<0.01);CAS 0,1,2,3,4级尿微量白蛋白水平比较差异均有统计学意义(P<0.05)。结论血脂正常的原发性高血压患者微量白蛋白尿与CAS发生及程度呈正相关。

Objective To investigate the relationship between microalbuminuria level and carotid atherosclerosis in patients with hypertension and normal blood lipid.Methods A total of 169 patients with primary hypertension and normal blood lipid were divided into carotid atherosclerosis plaque group（92 cases） and non-carotid atherosclerosis plaque group（77 cases） after the measurement of intima-media thickness of bilateral carotid arteries by ultrasonography.The degree of carotid atherosclerosis was divided into 0 to 4 levels.The level of microalbuminuria was detected.Results The level of microalbuminuria was significantly higher in carotid atherosclerosis plaque group than that in non-carotid atherosclerosis plaque group（P0.01）.There was a significant difference in microalbuminuria level between each two carotid atherosclerosis degrees from 0 to 4（P0.05）.Conclusion The formation of carotid atherosclerosis plaque is positively correlated with the increased microalbuminuria level in patients with hypertension and normal blood lipid.