妊娠期肝内胆汁淤积症孕妇肝功能变化与母儿预后关系的探讨

THE RELATIONSHIP BETWEEN THE PREGNANCY SERUM BILE ACID LEVEL OF INTRAHEPATIC CHOLESTASIS OF PREGNANCY AND PROGNSIS OF MOTHER AND FETUS

目的:探讨妊娠期肝内胆汁淤积症(ICP)孕妇肝功能变化与母儿预后的关系。方法:对我院2005～2010年确诊为ICP的140例孕妇临床资料进行回顾性分析。结果:血清谷丙转氨酶(AL T)>40 U/L、总胆红素(TBIL)>28μmol/L的孕妇,产后出血及早产、胎儿窘迫的发生率增高,且ALT水平越高,其发生率越高。结论:ICP孕妇肝功能的变化可预测母儿预后,ALT及TBIL水平升高者胎儿预后不佳,必须高度重视,严密监护,适时终止妊娠。

Objective：To investigate he relationship between the pregnancy serum bile acid level of intrahepatic cholestasis of pregnancy （ICP） and prognosis of mother and fetus in intrahepatic cholestasis of pregnancy.Methods：Clinical data of 140 cases with complete history and delivery record were retrospectively analyzed between 2005 to 2010.Results：the pregnancy serum glutamic pyruvic transaminase（ALT） 40 U/ L、Total bilirubin（TOIL） 28μmol/ L,the incidences of postpartum hemorrhage and premature birth and fetal distress in studying group were higher than thosein control group.The higher AL T level is,the higher it s incidence rate occurs. Conclusion：The maternal hepatic function can be used to prognosis prognosis of mother and fetus.The ALT of mothers with high level serum transaminase and bilirubin is bad,so t hey must be taken great attention and monitored closely,the pregnancy should be ended timely.