非甾体类抗炎药相关性溃疡并出血临床特征

Nonsteroidal Anti-inflammatory Drugs Associated Peptic Ulcer Bleeding with 69 Cases Analysis

【目的】总结分析非甾体类抗炎药相关性溃疡并出血的临床特征。【方法】回顾性分析我们科2007年2月至2011年1月4年间收治的非甾体类抗炎药相关性溃疡并出血住院患者69例的临床资料,与同期未服用非甾体类抗炎药的消化性溃疡并出血患者的临床资料进行比较与分析。【结果】NSAID组的69例患者在年龄构成,合并使用抗凝药物及糖皮质激素,腹痛症状,溃疡发生部位与数量,与消化性溃疡并出血的非NSAID组比较,差异具有统计学意义(P<0.05)。【结论】非甾体类抗炎药相关溃疡并出血引起腹痛症状较少,胃溃疡发生率高于十二指肠溃疡,多发溃疡发生率较高,在60岁以上老年人多见,导致60岁以上病例贫血程度更严重。

[ Objective ] To investigate the clinical characters of nonsteroidal anti-inflammatory drugs （NSAID） associated peptic ulcer bleeding through retrospective analysis. [Methods]Four hundred ninety-nine patients who were hospitalized in our wards diagnosed as peptic ulcer bleeding from February 2007 to January 2011 were divided into two groups according to taking NSAID or not. [Results] Sixty-nine cases （13.$%） with NSAID associated peptic ulcer bleeding were included. Compared with 430 cases without NSAID associated, there were significant differences in age, gender, co-administration with anti-coagulant drugs or steroids, location and amount of ulcers, severity of anemia in elder patients （P 〈 0.05）. [Conclusions] NSAID associated peptic ulcer bleeding mainly occurred in stomach with more multiple ulcers, while patients seldom complained of epigastric pains. These ulcers were more common in 60-year-old or above patients, who suffered from more severe anemia.