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病毒载体在帕金森病基因治疗中的最新进展与应用 被引量:1

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摘要 帕金森病(Parkinson's disease,PD)是一种是以中脑黑质多巴胺能神经元变性坏死、多巴胺合成减少为特征的中枢神经系统退行性疾病。目前治疗手段主要有药物治疗、手术治疗、基因治疗。传统药物只能减缓症状但不能阻止病情的发展,且会引起药物不良反应。而手术治疗帕金森病。
出处 《医学研究杂志》 2011年第12期22-24,共3页 Journal of Medical Research
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  • 1徐铁军,喻启桂,刘露霞,朱治远.单纯疱疹病毒Ⅰ型SM_(44)株和17Syn~+株用作跨神经元追踪示踪物的实验研究[J].神经解剖学杂志,1994,10(3):197-202. 被引量:3
  • 2[1]Nan X, Ng HH, Johnson CA, et al. Transcriptional repression by the methyl- CpG binding protein MeCP2 involves a histone deacetylase complex[ J]. Nature, 1998, 393: 386 -389.
  • 3[2]Nan X, Campoy FJ, Bird A. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin[ J]. Cell, 1997,88:471 -481.
  • 4[3]Amir RE, Van den Veyver IB, Wan M, et al. Rett syndrome is caused by mutations in X - linked MECP2, encoding methly - CpG -binding protein[J]. Nat Genet, 1999, 23: 185- 188.
  • 5[4]PAN H, WANG YP, BAO XH, et al. MECP2 gene mutation analysis in Chinese patients with Rett syndrome [ J ]. Eur J Hum Genet,2002, 10:484-486.
  • 6[5]Shahbazian MD, Zoghbi HY. Rett syndrome and MeCP2: linking epigenetics and neuronal function[J]. Am J Hum Genet, 71: 1259 -1272.
  • 7[6]Estibeiro P and Godfray J. Antisense as a neuroscience tool and therapeutic agent [ J ]. Trends in Neurosciences, 2001, 24 ( 11 suppl ):S56 - S62.
  • 8[7]Weiss B, Davidkova G, ZHOU LW. Antisense RNA gene therapy for studying and modulating biological processes[J]. Cell Mol Life Sci,1999, 55:334-358.
  • 9[8]Fraefel C, Song S, Lim F, et al. Helper virus - free transfer of herpcs simplex virus type 1 plasmid vectors into neural cells[ J]. J Virol, 1996,70:7190 -7197.
  • 10[9]ZHANG GR, WANG XD, YANG TZ, et al. A tyrosine hydroxylase - neurofilament chimeric promoter enhances long - term expression in rat forebrain neurons from helper virus - free HSV - 1 vectors [ J ].Brain Res Mol Brain Res, 2000, 84:17 -31.

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  • 1Monel B,Beaumont E,Vendrarae D ,et al. HIV cell-to-cell trans-mission requires the production of infectious virus particles and doesnot proceed through env-mediated fusion pores [ J ]. J Virol,2012,86 (7):3924-3933.
  • 2Huo LR, Ju W, Yan M,et al. Identification of differentially expressedtranscripts and translatants targeted by knock-down of endogenousPCBP1[J]. Biochimicaet Biophysica Acta, 2010, 1804 (10):1954-1964.
  • 3闻玉梅.慢病毒感染[J].国外医学参考资料:流行病学传染病学分册,1977,4(4):146-150.
  • 4仇素英.慢病毒感染[J].山东医学院学报,1979,24(3):109-116.
  • 5Lei Y,Joo KI,Zarzar J,et al. Targeting lentiviral vector to specificcell types through surface displayed single chain antibody and fusogen-ic molecule[J]. Virol J,2010,7 (2):35.
  • 6汪廷乐,宋萌.人永生化细胞系模型建立的方法[J].上海口腔医学,2010,19(2):212-215. 被引量:5
  • 7周雪萍,侯惠智,李英奇,杨斌盛,杨频.纳米Eu_2O_3对HEK-293T细胞的生物活性影响[J].化学学报,2011,69(1):106-110. 被引量:2
  • 8王兰英,霍丽蓉.PCBP1 RNAi重组慢病毒包装及筛选其稳定感染的神经细胞系[J].医学研究杂志,2012,41(2):42-45. 被引量:1

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