前列地尔加复方丹参对Strauss B级糖尿病足微循环的影响

Effect of Alprostadi and Complex Salvia Miltiorrhiza on Microcinculatory of Strauss B Degree Diabetic Feet

目的探讨前列地尔联合复方丹参治疗StraussB级糖尿病足的疗效。方法按Strauss分级标准选取70例StraussB级糖尿病足患者,实验组40例,除降糖、抗感染、换药等常规治疗外,另予前列地尔和复方丹参静脉滴注1次/日,疗程4周。对照组30例,仅降糖、抗感染、换药等常规治疗。以溃疡创面疗效判断标准观察足部溃疡创面愈合情况;以全血黏度(中切)、血浆黏度、血细胞比容、纤维蛋白原作为血液流变学观察指标。结果对照组和实验组病变创面均有改善,实验组有效率(92.5%)明显高于对照组(63.3%),差异有显著意义(P<0.01)。实验组血流变指标治疗前后的改善明显好于对照组,两组间差值的比较差异亦有显著意义(P<0.01)。结论前列地尔和复方丹参治疗糖尿病足的疗效肯定。长期应用能否根本逆转糖尿病足的血管病变沿需进一步观察和探讨。

Objective To investigate the curative effect of alprostadi and complex salvia miltiorrhiza on microcinculatory of strauss bdegree diabetivteet. Methods Totally 70 cases of diabetic feet belone to B grade according to the Srauss classify were selected to be the objects. 40 cases were the experimental group,who were treated by not only routine treatments such as control blood glucose, control infextation and change dressings, but also Alprostadil and complex prescription intravenous drip once a day, continued for four weeks as the treatment course. 30 cases were the control group,who were treated by only routine treatments such as control blood glucose, control infextation and change dressings. The heal information of feet ulcer raw surface were observed according to the curative effect judgement standard for ulcer raw surface. The haemorheology index such as blood viscosity（ middle cut） , plasma viscosity, volume of packed red cells and fibrinogen were observed. Results There were the improvement in the pathological change of raw surface either the control group or the experimental group. The effective ratio of the experimental group（92.5% ） was higher than of the control group（63.3% ）. There was the significance difference between them（P 〈 0.01 ）. The improvement from pretherapy to post -treatment of the experimental group was better than that of the control group,there was the significance difference （P 〈 0.01 ） between them. Conclusion The curative effect of treating diabetic feet by alprostadil and complex prescription is positive. It is necessary to observe and investigate whether it can fundamental reverse the vasculopathy of diabetic feet by using this two medicines for long - term.