女性慢性充血性心力衰竭患者血清CA125水平与其若干临床表现的相关性

Correlation between Serum CA125 Level and Several Clinical Signs in Female Patients with Congestive Heart Failure

目的观察女性慢性充血性心力衰竭(CHF)患者的血清CA125水平及其与相关临床表现之间的关系,评估血清CA125水平在慢性充血性心力衰竭患者诊治中的价值。方法收集自2006年1月～2010年6月期间在笔者医院住院治疗的女性慢性心力衰竭的患者69例,排除妇科肿瘤等影响血清CA125水平的疾病,临床资料完整并有血清CA125检测报告。对其与CHF相关临床表现之间的关系进行回顾性统计分析。结果血清CA125水平的高低与患者年龄大小及有无双下肢水肿无相关性,而患者左心室射血分数的降低、左心室舒张末内径的的增大、出现胸腔积液和(或)肺水肿均可促进血清CA125水平的升高。结论血清CA125水平与女性慢性充血性心力衰竭的部分临床表现有一定的关联,在排除恶性肿瘤及其他非心源性引起的血清CA125升高的情况下,血清CA125检测可作为对慢性充血性心力衰竭女性患者左心室心排量及失代偿评估的一项客观指标。

Objective To observe the correlation between serum CA125 level and several clinical signs in female patients with con- gestive heart failure （CHF） , and to evaluate the role of serum CA125 level in the treatment of CHF. Methods Totally 69 female patients with CHF were collected from January 2006 to June 2010 in our hospital during hospitalization. Diseases which influenced the serum CA125 level such as gynecological tumors were excluded. Clinical data were complete and serum CA125 inspection report was given. The serum CA125 level and clinical signs of CHF were analyzed retrospectively. Results The serum CA125 level was not correlated with the patient＇s age and edema of legs. The lower of left ventrieular ejection fraction, enlargement of end - diastolic left ventrieular diameter, pleural effusion and/or pulmonary edema could promote the increased serum CA125 level. Conclusion There is a correlation between serum CA125 level and part of the clinical signs in female CHF patients when other diseases which could influence the serum CA125 level were excluded. Serum CA125 level could be used as an objective evaluation index of left ventricular heart discharge capacity and decompensation in female CHF patients.