原发于前列腺的血管内大B细胞淋巴瘤1例报道及文献复习

Primary prostatic intravascular large B cell lymphoma:A case report and literature review

目的:探讨原发于前列腺的血管内大B细胞淋巴瘤(Intravascular large B cell lymphoma,IVLBCL)的临床病理特征及治疗效果。方法:对1例原发于前列腺的IVLBCL进行组织学观察、免疫组化染色检测和临床随访,并复习了文献报道的6例前列腺IVLBCL。结果:IVLBCL累及前列腺的患者中位年龄为68岁,患者常出现下尿路阻塞症状,体检发现前列腺肥大。前列腺组织病理活检发现前列腺间质小血管内异形的淋巴样细胞增生。免疫组化染色结果显示瘤细胞表达B细胞标记物CD20和CD79α,细胞增殖核抗原Ki67阳性率较高。患者在确诊为前列腺血IVLBCL后,接受CHOP化疗或联合利妥昔单抗治疗效果较好。结论:仅累及前列腺的IVLBL患者经手术切除前列腺并结合药物化疗预后较好。

Objective：To investigate the clinicopathological characteristics of primary prostatic intravascular large B cell lymphoma（IVLBCL） and the prognosis of the patients.Methods：One case of primary prostatic IVLBCL was studied by microscopic observation,immunohistochemistry staining and the clinical follow up.6 cases of prostatic IVLBCL reported in the literature were reviewed.Results：The median age of prostatic IVLBCL patients was 68-year-old.They often complained of progressing dysuria,and their prostatic enlargement was revealed.After the prostatectomy,the pathological biopsy revealed that dysplastic lymphoid cells proliferating in prostatic interstitial vessels.The immunohistochemistry staining revealed that tumor cells had positive expression of B cell marker CD20 and CD79α,and many tumor cells had positive expression of Ki67.After diagnosed as primary prostatic IVLBL,the patients were treated with cyclophosphamide,doxorubincin,vincristine,and prednisolone（CHOP） and/or rituximab,With the good therapeutic effect.Conclusion：The primary prostatic IVLBCL patients have good prognoses after they undergo prostatic resection and chemotherapy.