TNF-α、高敏C反应蛋白与颈动脉粥样硬化超声影像的相关性

Relationship between TNF-α,hsCRP and ultrasonic imaging of carotid atherosclerosis

【摘要】目的：探讨血清TNF-α水平及高敏C反应蛋白与颈动脉粥样硬化程度之间的关系。资料与方法：选取颈动脉超声检查确诊的颈动脉荆样硬化患者62例，其中男41例，女21例，年龄52-75岁，平均（65．9±10．2）岁；同期选取无高血压、糖尿病、冠心病或脑血管疾病且颈动脉超声检查正常者25例，男15例，女10例，年龄52-76岁，平均（64．6±8．2）岁。采用ELISA法检测血清TNF-α水平、高敏C反应蛋白，并同健康人比较。对血清TNF-α水平、高敏C反应蛋白与颈动脉粥样硬化程度进行相关性分析，结果：预动脉粥样硬化超声检查示内膜回声增强变厚，表面粗糙，连续性差，有中断现象。可见形态不-α大小不等的粥样斑块、颈动脉喇样硬化患者血清TNF-α水平为（51．4±6．6）μg／L，显著高于健康人（8_8±1．2）μg／L，P〈0．01；高敏C反应蛋白为（8．8±0．56）mmol／L，高于健康人（8.3±0．43）mmol／L，P〈O．01．且与颈动脉粥样硬化严重程度分级呈正相关（P〈0．01）。结论：颈动脉粥样硬化患者血清TNF-仅水平显著升高，高敏C反应蛋白水平升高且与病变严重程度呈正相关。

Objective： To study the relationship between serum level of TNF-α, hsCRP and ultrasonic imaging of carotid atheroselerosis. Materials and Methods： The patients with final diagnosis of carotid atherosclernsis as well as healthy individ- uals were selected and their serum level of TNF-α, hsCRP detected. Statistic methods were used in the interrelationship anal- ysis of the serum level of TNF-α, hsCRP and degree of carotid atheroselerosis. Results： Totally 62 patients with carotid atherosclerosis and 25 healthy individuals were enrolled. The carotid atherosclerosis with ultrasonic image of intimae echo en- hancement, rough surface, worse continuity and different shape as well as inequality of size of atheroselerotie plaque were analysed. The sermn level of TNF-α in patients with carotid atherosclerosis was （51.4±6.6）μg/L, and was （8.8±1.2）μg/L in healthy individuals, which had significant difference （P〈0.01）. The serum level of hsCRP in patients with carotid atherosclerosis was （8.8±0.56）mmol/L, and （8.3±0.43）mmol/L in healthy individuals, which had significant difference （P〈0.01）. It had positive correlation with degree of carotid atherusclerosis （P〈0.01）. Conclusion： The serum level of TNF-α, hsCPtP was significantly higher than those of the healthy individuals, and has positive relation with degree of carotid atherosclemsis.