肉毒杆菌毒素A辅助复健训练治疗儿童痉挛型脑瘫的疗效观察

Clinical research on botulinum toxin type A combining rehabilitation training for the treatment of children cerebral palsy

目的:探讨采用肉毒杆菌毒素A辅助复健训练治疗儿童痉挛型脑瘫的临床疗效。方法:将本院2009年3月-2011年3月收治的32例脑性瘫痪患儿随机分成2组:对照组16例,试验组16例。其中,对照组给予常规的复健训练治疗,试验组则给予注射肉毒杆菌毒素A辅助复健训练治疗。结果:经过治疗后,试验组的粗大运动(GMFM)功能评分显著高于对照组(P<0.05);试验组的肌张力改良Ashworth评分相比对照组显著性降低(P<0.05);试验组的腘窝角、足背屈角、足外展角的活动范围相比对照组均有显著性改善(P<0.05)。结论:采用肉毒杆菌毒素A辅助复健训练治疗儿童脑瘫的临床疗效显著。

To observe the clinical effect of botulinum toxin type A combining rehabilitation for the treatment of children cerebral palsy METHODS. Thirtytwo cases of children cerebral palsy admitted to hospital from March 2009 to March 2011 were randomly divided into two groups, control group（n= 16） and treatment group（n= 16）. The control group was given conventional rehabilitation training; the treatment group was also given injection of botulinum toxin A. The clinical effects in 2 groups were observed and compared. RESULTS： After treatment, the GMFM score in the treatment group was significantly higher than that in the control group （P〈0.05）. The Ashworth score in the treatment group was significantly lower thanthat in the control group （P〈0.05）; and the popliteal fossa angle, foot disaffection angle and abduction angle in the treatment group were superior to those in the control group（P〈0.05）. CONCLUSION： There is a significant clinical effect of hotulinum toxin type A combining rehabilitation for the treatment of children cerebral palsy.