老年2型糖尿病患者血尿酸与骨密度关系的研究

Association between uric acid and bone mineral density in elderly people with type 2 diabetes mellitus

目的分析老年2型糖尿病患者血尿酸与骨密度是否相关。方法测定121例老年2型糖尿病患者的骨密度及血尿酸浓度,按照性别分为两组,应用SPSS17.0对数据进行相关及回归分析。结果老年2型糖尿病患者血尿酸值与年龄及多部位骨密度值相关,与L2、大转子、股骨干等部位的骨密度值相关性显著(P<0.01)。结论动态监测血尿酸值有利于老年2型糖尿病患者骨密度值减低的预防和治疗。

Objective To analyze the association of serum uric acid with bone mineral density in elderly people with type 2 diabetes mellitus. Methods Dual energy x-ray absorptiometry （DXA） was used to measure BMD of seven skeletal regions of lumbar spine （ L_2-L_4 ） , the left hip department （ femoral neck, Ward＇s triangle and greater trochanter） and femoral and uricase-peroxidase enzymatic method was used to measure serum uric in 121 elderly people with type 2 diabetes mellitus, in whom were divided into two groups：group I （the old man）and group l] （the postmenopausal women）. The data were analyzed by spssl7.0. Results The correlation analysis results showed that： In elderly people with type 2 diabetes mellitus, the serum uric acid level was positively and significantly related to bone mineral density of multi areas. Conclusion It is a good predictor to dynamically monitor the serum levels of UA in the elderly patients with type 2 diabetes mellitus with decrease of BMD, which benefits the prevention and treatment.