摘要
目的探讨Merkel细胞癌的临床病理特征、诊断和鉴别诊断、治疗及预后。方法回顾分析4例Merkel细胞癌患者的临床资料、组织病理形态和免疫组化结果。结果光镜下癌细胞呈巢索状弥漫排列,形态类圆形、空泡状,大小较一致,染色质呈细颗粒状。免疫组化示AE1/AE3、CK20、EMA、NSE、CgA、Syn和CD56(+)。结论Merkel细胞癌是一种高度恶性的皮肤原发性神经内分泌癌,掌握临床病理及免疫组化特征对该病的诊断和鉴别诊断具有重要意义。彻底切除病灶结合术后放疗或化疗是治疗Merkel细胞癌的主要手段。
Objective To investigate the clinicopathological features,diagnosis,differential diagnosis,therapy and prognosis of Merkel cell carcinoma.Methods The clinical data,histopathological changes and immunohistochemical expression were investigated and reviewed on four cases of Merkel cell carcinoma.Results Microscopically,the tumor cells were round and vacuole,showing conformity in shape with fine granular cytoplasm;the arrangement of the cells was in nest-like structure or diffuse.Immunohistochemical staining for CK,EMA,NSE,CgA,Syn and CD56 were positive in most tumor cells.Conclusion Merkel cell carcinoman is a high-grade and primary neuroendocrine carcinoma of the skin.Understanding the characteristics of clinicopathology and immunohistochemistry plays an important role in the diagosis and the differential diagnosis from other disease.The most effective way for treating Merkel cell carcinoma is completely surgical ecxision with radiotherapy or chemotherapy.
出处
《诊断病理学杂志》
CSCD
2011年第6期428-431,共4页
Chinese Journal of Diagnostic Pathology
