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家族性胃癌的遗传学特征 被引量：1

Genetic features of familial gastric cancer
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摘要 胃癌是一种在世界范围内常见的消化系恶性肿瘤,虽然近年来发病率有所下降,但仍是亚洲国家发病率最高的恶性肿瘤之一.约有10%的患者表现出家族聚集现象,1%-3%的病例具有遗传倾向,提示家族性胃癌的发生具有一定的遗传学基础.遗传性弥漫型胃癌作为家族性胃癌的一种亚型,1/3的家系具有编码细胞间黏附分子E-cadherin基因的种系突变,其他的易感基因还包括MMR基因、MET基因等,本文试从遗传学角度对家族性胃癌作一综述. Chao Sun,Xin Chen,Bang-Mao Wang,Department of Gastroenterology,Tianjin Medical University General Hospital, Tianjin 300052,China
作者 孙超 陈鑫 王邦茂
机构地区 天津医科大学总医院消化科
出处 《世界华人消化杂志》 CAS 北大核心 2011年第32期3318-3322,共5页 World Chinese Journal of Digestology
关键词 家族性胃癌 遗传学特征 肿瘤 Familial gastric cancer Genetic features Tumor
分类号 R735.2 [医药卫生—肿瘤]
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参考文献27

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世界华人消化杂志
2011年 第32期

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