DNA甲基化与胃癌的研究进展

DNA methylation and gastric cancer

甲基化是一种以胞嘧啶为基础的DNA改变,他从表观遗传的角度调控许多真核生物的生长代谢,并对正常生物学行为和疾病的发生具有重要意义.DNA甲基化是一种重要的基因表观遗传改变,调控细胞的许多进程.已经发现越来越多的人类疾病包括癌症与异常的DNA甲基化有关.最近快速发展的癌症表观遗传学领域揭示了涉及癌症表观遗传的每一个组件的广泛重组现象,如DNA脱甲基化.本文主要综述了当前DNA甲基化改变在胃癌与正常组织细胞的研究比较,他在胃癌发生发展中的角色及利用这些已知指导更有效的治疗趋势.

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many eukaryotes that has important implications for normal biology and disease.DNA methylation is a crucial epigenetic modification of the genome that is involved in regulating many cellular processes. A growing number of human diseases including cancer have been found to be associated with aberrant DNA methylation.Recent advancements in the rapidly evolving field of cancer epigenetics have described extensive reprogramming of every component of the epigenetic machinery in cancer,such as DNA demethylation. In this review,we discuss the current understanding of alterations in DNA methylation composing the epigenetic landscape that occurs in gastric cancer compared with normal cells, the roles of these changes in gastric cancer initiation and progression,and the potential use of this knowledge in designing more effective treatment strategies.