P38 MAPK信号通路主要功能及对肝纤维化的作用

P38 MAPK signaling pathway:biological functions,roles in the pathogenesis of liver fibrosis and common research methods

肝纤维化是多种慢性肝病发展演变为肝硬化的必经阶段,肝星状细胞(hepatic stellate cells,HSC)的活化与增殖是肝纤维化发生的关键环节,目前与HSC有关的信号转导机制是普遍的研究焦点.干预HSC的研究主要有:干扰细胞信号转导通路,抑制炎症反应,对抗氧化应激,调节相关细胞因子活性等.本文综述了P38 MAPK信号通路的主要功能、常见研究方法及对肝纤维的作用机制,以期为实验研究提供思路.

The activation and proliferation of hepatic stellate cells（HSC） are the key events in hepatic fibrogenesis.Now the research about the mechanisms of action of HSC-related signal transduction has become a hot topic.This article reviews the biological functions of the p38 MAPK signaling pathway and its roles in the pathogenesis of liver fibrosis and summarizes common research methods for this signaling pathway.