鱼类抗菌肽的研究进展

Research progress on antimicrobial peptides in fish

抗菌肽是一类广泛存在于生物界的小分子短肽,具有广谱的抗菌、抗病毒、抗寄生虫及抗癌等生物活性。它是鱼类自身先天免疫系统的重要组成部分,结构复杂,种类多样。本文综述了目前发现的鱼类抗菌肽的结构特点、种类、生物学功能、抗菌机制以及基因工程上的研究进展。

Antimicrobial peptides, a family of short-chain peptides, are widely spread in biological world. Besides broad-spectrum antibacterial activity, Antimicrobial peptides have biological activities on the resistance of virus, parasite and tumor. Antimicrobial peptides is a key component of the innate immune systems of fish, these molecules structures are complicated and diversiform. Based on the findings of antimicrobial peptides from fish, this review discusses the structural features, categories, biological properties, antibacterial mechanisms, and its progress in the field of gene engineering.