缬沙坦和阿托伐他汀联合胺碘酮治疗阵发性心房颤动疗效观察

Clinical effect of valsartan, atorvastatin combined with amiodarone on patients with paroxysmal atrial fibrillation to maintain sinus rhythm

目的 评价缬沙坦和阿托托他汀联合胺碘酮治疗阵发性心房颤动的临床疗效.方法 120例阵发性心房颤动患者完全随机分为治疗组（68例）和对照组（52例）,全部患者经过口服或静脉注射胺碘酮或电复律恢复窦性心律后,对照组给予胺碘酮口服,第1周600 mg/d,第2周减至400 mg/d,第3周减至200mg/d,并以200 mg/d剂量用药至满1年.治疗组加用缬沙坦80 mg/d,阿托伐他汀钙胶囊10mg/晚.观察2组患者治疗第3、6、9、12个月的窦性心律维持率.结果 治疗3个月,治疗组、对照组窦性心律维持率分别为91.2％ （62/68）、86.5％ （45/52）,2组差异无统计学意义（P＞0.05）；治疗6、9和12个月,治疗组和对照组窭性心律维持率分别为86.8％（ 59/68）、85.3％ （58/68）、82.4％（56/68）和71.2％（ 37/52）、65.4％（ 34/52）、59.6％（31/52）,差异有统计学意义（P＜0.05）.结论 缬沙坦和阿托伐他汀联合胺碘酮治疗阵发性心房颤动疗效优于单用胺碘酮治疗.

Objective To evaluate the clinical effect of valsartan,atorvastatin combined with amiodarone on patients with paroxysmal atrial fibrillation to maintain sinus rhythm.Methods One hundred and twenty patients with paroxysmal atrial fibrillation were chosen and divided into treatment group （68 cases） and control group （52 cases）.After all patients recovered sinus rhythm via taking amiodarone orally or intravenous injection or electrical conversion.The control group took 600 mg of amiodarone orally each day in the first week,400 mg per day in the second week,200 mg per day in the third week and maintained 200 mg per day afterwards.The treatment group used additional 80 mg of valsartan each day and 10 mg of atorvastatin calcium capsule every night.The maintenance ratio of sinus rhythm of the two groups of patients after three,six,nine and twdve months of treatment was observed.Results After three months of treatment,the maintenance ratio of sinus rhythm of treatment group and control group were 91.2% （62/68） and 86.5% （45/52） respectively.The difference between the two groups had no statistical significance（P 〉0.05）.After six,nine and twelve months of treatment,the maintenance ratio （%） of sinus rhythm of treatment group/control group was 86.8% （59/68）,85.3% （58/68）,82.4% （56/68） ; 71.2% （37/52）,65.4% （ 34/52 ）,59.6% （ 31/52 ）,respectively.The differences had statistical significance （ P 〈 0.05）.Conclusion The curative effect of valsartan,atorvastatin combined with amiodarone on the patients with paroxysmal atrial fibrillation to maintain sinus rhythm is better than that of the treatment with only amiodarone.