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LC-MS/MS法快速筛选保健食品中非法添加的18种止咳平喘化学成分 被引量:16

Screening for 18 Mixed Illegally Cough-Relieving Chemical Composition in Health Food by LC-MS/MS
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摘要 目的:建立保健食品中非法添加的18种止咳平喘化学成分的快速筛选方法。方法:采用液相色谱-串联质谱法(LC-MS/MS)以Polaris 5 C18-A(2.0mm×50mm,5μm)为分析柱,流动相采用0.1%甲酸和甲醇进行梯度洗脱,电喷雾电离(ESI)、多反应监测(MRM)扫描方式,对保健食品中非法添加的18种止咳平喘化学成分进行筛选分析。结果:建立了快速分离检测保健食品中18种非法添加成分的测定方法,检测限低于2ng。结论:该方法专属性强、灵敏度高,适用于止咳平喘类保健品中非法添加成分的筛选及确证工作。 Objective:To establish a liquid chromatography-tandem mass chromatography(LC-MS/MS) method for the simultaneous screening 18 kinds of cough-relieving cough asthma chemical compositions in health food.Methods:This method involves liquid chromatography-tandem mass spectrometry,the separation was conducted by Varian Polaris 5 C18-A(2.0mm×50mm,5μm).The mobile phase was consisted of 0.1% formic and methanol.The target compounds were analyzed with LC-MS/MS-ESI,multiple-reaction monitoring(MRM) was used to screen illegal chemical compositions in health food.Results:A fast and sensitive liquid chromatography mass spectrometric(LC/MS) method for the simultaneous screening for illegal chemical compositions was described.The LOD of these substances were below 2ng.Conclusion:The method was sufficiently selective and sensitive to detect illegal chemical compositions in health food.
出处 《中华中医药学刊》 CAS 2012年第1期172-175,共4页 Chinese Archives of Traditional Chinese Medicine
基金 南京市科技发展计划项目(200801069)
关键词 高效液相色谱-质谱 多反应监测 止咳平喘类保健品中非法添加成分 快速 LC-MS/MS multiple-reaction monitoring(MRM) mixed illegally chemical compositions rapid
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