纤维蛋白原载脂蛋白A脂蛋白的测定对冠心病的诊断价值

The Diagnosis Value of Fibrinogen Apolipoprotein A Lipoprotein for Coronary Heart Disease

目的:探讨纤维蛋白原(FIB)、载脂蛋白A、脂蛋白的各项指标在冠心病(CHD)发病中的诊断价值。方法:随机选择冠心病患者50例,健康人50例,分为两组冠心病组50例、健康组50例。用日本HITACHI7180全自动生化分析仪分别测定这两组载脂蛋白A1(ApoA1)、和高密度脂蛋白(HDL)、低密度脂蛋白(LDL);用血清凝胶电泳法测定极低密度脂蛋白(VLDL)及乳糜微粒(CM);用日本Sysmex公司的全自动血凝仪测定FIB;酶联免疫吸附法测定载脂蛋白A5(ApoA5),并分析它们与CHD的相关性。结果:冠心病组与健康组比较,冠心病组的ApoA5水平明显降低(P<0.05),FIB、CM、LDL、VLDL、均明显升高(P<0.01或P<0.05),而HDL和APOA1水平无显著差异(P>0.05)。结论:FIB、LDL、VLDL、CM的检测可作为冠心病的实验室诊断指标,对于临床上诊断CHD有着重要价值。

Objective： To study the value of the fibrinogen（FIB）,various indexes of apolipoprotein A and lipoprotein in diagnosing coronary heart disease（CHD）.Method： Random selection of 50 patients with coronary artery disease and 50 healthy people were divided into CHD group（50 patients） and health group（50 healthy people）.HITACHI7180 automatic biochemistry analyzer was measured at apolipoproteinA1（ApoA1）,High density lipoprotein（HDL） and low density lipoprotein（LDL）.Serum SDS-PAGE electroporesis was measured at very low density lipoprotein（VLDL） and chylomicron（CM）.Enzyme linked immunosorbent assay（ELISA）was measured at the two groups of apolipoproteinA5（ApoA5）,Sysmex automatic coagulometer was measured at fibrinogen（FIB）.And analyzed the relationship between them and CHD.Result： Compared CHD group and health group,ApoA5 level of CHD group decreased obviously（P0.05）,FIB,LDL,VLDL and CMsignificantly increased（P0.01 or P0.05）,HDL and APOA1 levels were not significant difference（P0.05）.Conclusion：FIB,LDL,VLDL and CM detection can be used as CHD laboratory diagnosis index,It＇s important for the diagnosis of coronary heart disease.