摘要
巨噬细胞作为一种具有可塑性和多能性的细胞群体，在正常组织中巨噬细胞均以M2型存在，具有抗炎和免疫调节等保护作用，而在肥胖个体脂肪组织中巨噬细胞大量渗入且多以M1型存在，在诱导机体炎症反应和胰岛素抵抗中发挥重要作用。本文就巨噬细胞的生物学特性及相关特征性基因表达与肥胖引起胰岛素抵抗的相关性作一综述。
Macrophage is a cell population with the plasticity and multipotential and with function of anti - inflammation and im- munoregulation in most presence of M2 macrophage in normal tissue. M1 macrophage infiltration in adipose tissue of obesity body plays an important role in pro - inflammation and insulin resistance. This paper reviews the characters of maerophage, some marker genes and the relationship between obesity and insulin resistance.
出处
《国际老年医学杂志》
2012年第1期15-18,共4页
International Journal of Geriatrics
关键词
巨噬细胞
胰岛素抵抗
抗炎
免疫调节
Macrophage
Insulin resistance
Anti - inflammation
Immunoregulation
